Prof. Zakhor received the B. S. degree from California Institute of Technology, Pasadena, and the S. M. and Ph. D. degrees from Massachusetts Institute of Technology, Cambridge, all in electrical engineering, in 1983, 1985, and 1987 respectively. She was a General Motors scholar from 1982 to 1983, was a Hertz fellow from 1984 to 1988, received the Presidential Young Investigators (PYI) award, and Office of Naval Research (ONR) young investigator award in 1992. In 2001, she was elected as IEEE fellow and received the Okawa Prize in 2004.
She co-founded OPC technology in 1996, which was later by Mentor Graphics (Nasdaq: MENT) in 1998, and UrbanScan Inc. in 2005 which was acquired by Google in 2007. The technology behind 3D Google Earth was originally developed in her lab at U.C. Berkeley.